A University of Kentucky College of Medicine team led by Dr. Hu Huang reports in Aging Cell that genetically locking the RNA-binding protein tristetraprolin (TTP) in a stable, active state in 22-month-old C57BL/6J mice restores grip strength, trabecular bone-volume fraction and treadmill endurance toward young-adult levels while measurably reducing systemic levels of the senescence-associated inflammatory cytokines IL-6, TNF-α and CXCL1. The paper, posted online May 16 and amplified through a ScienceDaily release on May 18, 2026, identifies TTP-driven AU-rich-element-mediated mRNA decay as the brake on chronic 'inflammaging' that progressively fails with age.
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