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Common Asthma Drug Montelukast Shown to Supercharge Cancer Immunotherapy in Lab Studies

Scientists at Northwestern University have discovered that montelukast, an asthma and allergy drug taken by millions worldwide, can reverse a key mechanism that makes aggressive cancers like triple-negative breast cancer resistant to immunotherapy. Published in Nature Cancer, the study found that blocking the CysLTR1 pathway with montelukast restored immune cell function and significantly slowed tumor growth in mice, with human clinical trials now being planned.